Best ergonomic mouse: great mice designed for the ultimate comfort

Ergonomic mouse and normal computer mouse. Black vertical optical computer mouse with ergonomic design, designed to reduce injuries such as carpal tunnel syndrome, arthritis.
(Image credit: Nor Gal / Shutterstock)

The best ergonomic mouse will give you that great computing experience and alleviate any chronic pain you may be suffering from due to long-term mouse use. Such a mouse is designed so you can comfortably work on your computer without worrying about neck, shoulder, arm and wrist pain – or at least alleviate any pain you’re already experiencing.

Trust us; just like an ergonomic keyboard, an excellent mouse that focuses on comfort and ergonomics will give you a much better experience on your laptop or desktop. Not only are they made to save you from any computing injuries, but they’re comfortable to use and help you be much more productive, no matter if you’re working on a creative project or getting through your day-to-day work.

Here are the best ergonomic mice 2022 has to offer to help you easily find the right one. And, with our price comparison tool included, you might even score a great mouse deal.

Best ergonomic mouse: Logitech Ergo M575 Wireless Trackball

(Image credit: Logitech)

1. Logitech Ergo M575 Wireless Trackball

Best ergonomic trackball mouse

Specifications

Interface: Wireless
Buttons: 5
Ergonomic: Right-handed

Reasons to buy

+
Affordable
+
Reliable and accurate

Reasons to avoid

-
A bit of a learning curve
-
Battery not rechargeable

If you’re looking for the best ergonomic mouse overall, the Logitech Ergo M575 Trackball mouse is a terrific candidate for the title – though probably not if you don’t like using trackballs. There is a bit of a learning curve here. After all, your thumb does all the scrolling and gliding while your hand and arm sit nice and relaxed. 

The ergonomic feature is two-fold as well, as its palm rest is shaped to ergonomically fit and support your hand, drastically reducing fatigue. Of course, this being a great mouse, you can expect excellent performance, robust build, and long battery life as well. The only thing that could have made this mouse better is if it was rechargeable.

Best ergonomic mouse: Razer Pro Click

(Image credit: Razer)

2. Razer Pro Click

Best ergonomic mouse for productivity

Specifications

Interface: Wired/Wireless
Buttons: 8
Ergonomic: Right-handed

Reasons to buy

+
Precise ergonomics
+
Multi-device connectivity

Reasons to avoid

-
No USB-C port
-
Not particularly portable

The Razer Pro Click is more than just about looking good. This wireless mouse is perfect for professionals inside and out, matching its clean, elegant design with a high performance worthy of its target users. More than that, it’s engineered to keep your wrist at the optimum angle of 30 degrees, the palm rest supporting your hand in order to keep your wrist off your desk surface. 

Of course, there’s one other feature to love here – the several different connectivity options that will let you connect it to several different devices. If only it came with a USB-C port and a lower price tag. 

Read the full review: Razer Pro Click

Best ergonomic mouse: Logitech MX Master 3

(Image credit: Logitech)

3. Logitech MX Master 3

Best ergonomic mouse for creatives

Specifications

Interface: Wireless
Buttons: 7
Ergonomic: Right-handed

Reasons to buy

+
App-specific customizations
+
Multi-device connectivity

Reasons to avoid

-
May be pricey for some
-
Right-handed users only
-

The Logitech MX Master 3 is one of the best mice we’ve ever tested, delivering excellent performance and offering app-specific customizations for maximum productivity and the most seamless workflows. With it, creative tasks are a breeze to get through, especially when you actually take the time to set those customizations. 

This adds to its ergonomic benefits while keeping you focused on your creative process. But it doesn’t stop there. Its curved form, especially at the palm rest, gives your hand the support it needs for long workdays, and its thumb rest, which doubles as another button, keeps your thumb resting comfortably instead of actively gripping the side. The long battery life and rechargeable battery are only cherries on top.

Read the full review: Logitech MX Master 3

Best ergonomic mouse: Anker 2.4G Wireless Vertical Ergonomic

(Image credit: Anker)

4. Anker 2.4G Wireless Vertical Ergonomic

Best vertical ergonomic mouse

Specifications

Interface: Wireless
Buttons: 5
Ergonomic: Right-handed

Reasons to buy

+
Cheap
+
Extremely ergonomic

Reasons to avoid

-
Steep learning curve
-
Non-rechargeable

The Anker 2.4G Wireless Vertical Ergonomic also wins the title of the best budget ergonomic mouse, being much cheaper than all the other picks on this list. However, when it comes to vertical ergonomic mice, it’s also the one to beat. 

The way it’s designed not only alleviates undue pressure we put on our wrist and hand, but also keeps all its buttons within easy reach so your fingers aren’t constantly extending unnaturally. Simply put, it encourages a more natural hold, which in turn minimizes strain. There are other things to love here as well: three DPI settings, a reliable 2.4GHz USB receiver, and good battery life. Oh yes, and the bargain-basement price as well.

Best ergonomic mouse: Microsoft Sculpt Ergonomic

(Image credit: Microsoft)

5. Microsoft Sculpt Ergonomic

Best ergonomic mouse for Windows

Specifications

Interface: Wireless
Buttons: 7
Ergonomic: Right-handed

Reasons to buy

+
Great form
+
Windows button is nifty

Reasons to avoid

-
Expensive for what it is
-
Not the most robust

The Microsoft Sculpt Ergonomic might remind you of a cute black ladybug, but much like most cute things, it’s a lot more capable than people give it credit for. Designed by Microsoft to specifically help prevent repetitive stress injuries, this mouse is sculpted to encourage your hand, wrist and forearm to take a more natural posture. Its palm rest also elevates your hand in order for your wrist to be in a more comfortable, pressure-reducing position as well as scoops up your thumb so that it’s not exerting unnecessary force when it doesn’t need to. 

Finally, Windows users will appreciate that it perfectly integrates with the OS, touting a strategically-placed Windows button so you can quickly access the Windows Start Menu without having to move the mouse.

Michelle Rae Uy
Buying Guides Editor

Michelle Rae Uy is the Buying Guides Editor here at TechRadar. She's a Los Angeles-based tech, travel and lifestyle writer covering a wide range of topics, from computing to the latest in green commutes to the best hiking trails. She's an ambivert who enjoys communing with nature and traveling for months at a time just as much as watching movies and playing sim games at home. That also means that she has a lot more avenues to explore in terms of understanding how tech can improve the different aspects of our lives.