It's now pretty much impossible to find an image that hasn't benefited from its magic touch.
From whitening teeth in billboard ads to foisting yet more lolcats on the world, its influence is enormous.
Inevitably that influence has been bad as well as good. In the right hands, image manipulation can be undetectable, but all too often Photoshop falls into the hands of the overworked, the shoddy and the idiotic.
That's why you end up looking at impossible furniture, terrifying teeth, really unfortunate hand placements, Viagra-powered aeroplanes and movie posters whose stars appear to have been replaced by mannequins.
It's fun to laugh at Photoshop disasters, but of course the technology can be used for evil, too. Ralph Lauren isn't the only fashion brand distorting women's bodies to sell products; it's just one of the ones whose Photoshoppers took things too far.
When you take all these things together, it's pretty clear that Photoshop hasn't just revolutionised photography and illustration: it's ruined photojournalism and killed our belief that the camera never lies.
Hasn't it? Perhaps not. As Hany Farid of Dartmouth College points out [PDF], "photography lost its innocence many years ago. The nearly iconic portrait of the US President Abraham Lincoln (circa 1860), for example, was a fake, and only the beginning of a long history of photographic trickery... history is riddled with photographic tampering."
As soon as images became digital, they became easier to manipulate - just as text, and music, and video have all become easier to manipulate. That's progress, not Photoshop.
In fact, there's a strong argument that Photoshop has made the world a better place. In the hands of satirists it quickly punctures politicians at their most pompous, while in the hands of the manipulators at Fark.com and B3ta.com it cracks us up laughing.
And for all we moan about unrealistic body images, surely it's better for Sarah Jessica Parker to be Photoshopped silly than to stick her unedited, Zelda-from-Terrahawks features on giant posters?
Ultimately Photoshop is just a tool - an incredibly powerful, world-changing tool, sure, but Adobe is no more responsible for the idiots who abuse it than Laslo Biro can be blamed for bad teenage poetry.
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Writer, broadcaster, musician and kitchen gadget obsessive Carrie Marshall (Twitter) has been writing about tech since 1998, contributing sage advice and odd opinions to all kinds of magazines and websites as well as writing more than a dozen books. Her memoir, Carrie Kills A Man, is on sale now. She is the singer in Glaswegian rock band HAVR.