Blow, the man behind upcoming PS4 exclusive The Witness and 2008's indie hit Braid, said that the next Xbox wasn't as appealing as a platform, with Microsoft aiming for a more all-rounded media console.
"To me they talk about a console that is not strictly about games," he told Edge. "It's trying to be the center of the living room device, which is fine and maybe it's the right thing for Microsoft to do, business-wise."
He added: "As a place to put the best, highest performing version of our game on, it doesn't seem as good a choice."
Blow also added that a rocky past relationship with Microsoft affected the decision to make The Witness a timed PS4 exclusive. The title was shown off during the PS4 reveal last month, and is Blow's first game since Braid.
Blow's comments might not deal too much damage to Microsoft at this stage, as most of what we're hearing about the Xbox 720 is nothing but speculation.
But with the Wii U and PS4 now out in the open, we're more interested than ever in what Microsoft is going to pull out of the bag.
Want to know more about Microsoft's next console? Watch our reveal video below!